She is well known for her rags to riches life story and for her eight-season, seven-figure contract with Calvin Klein. In 2012, she came in third on the Forbes top-earning models list, estimated to have earned $8.6 million in one year.
In 2001, Vodianova made a brief appearance in Roman Coppola's film CQ with Billy Zane. In 2010, she portrayed Medusa in the 2010 remake of Clash of the Titans. In October 2010, she landed her first leading acting role in a film adaptation of Albert Cohen's 1968 novel Belle du Seigneur, directed by Glenio Bonder and co-starring Jonathan Rhys Meyers, which was released in 2013.